Fig. 1: The effect of intravenous (IV) naloxone dose on opioid receptor blockade ~55 min after administration. | Neuropsychopharmacology

Fig. 1: The effect of intravenous (IV) naloxone dose on opioid receptor blockade ~55 min after administration.

From: Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade

Fig. 1

The bottom x-axis displays untransformed doses while the top x-axis shows the corresponding log10-transformed doses. The dashed horizontal line indicates full (90%) receptor blockade. MOR blockade (solid black curve) is based on the data in Table 1 (black dots). DOR (dot-dashed red curve) and KOR blockade (long-dashed blue curve) were approximated from MOR blockade using the relative receptor affinities of naloxone (Table S1). Semitransparent bands indicate 95% confidence band (black band), or range based on highest and lowest reported affinity ratio (blue and red bands; Table S1). The estimated ED50 for MOR, DOR and KOR blockade was 0.0023 (SE = 0.0004), 0.094 and 0.018 mg/kg, respectively.

Back to article page