Fig. 2: Ancestry-informative variables for Human Brain Collection Core (HBCC) donors.
From: Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort
Principal components analysis was applied to a pruned set of SNPs from HBCC samples (N = 1418) and 1000 Genomes samples combined in order to infer major ancestry distinctions among of HBCC samples. As can be seen in the scatter plot, HBCC samples clustered with the major population groups from 1000 Genomes. Note that density of points is not clear from this plot and that the majority of the HBCC samples cluster with the 1000 Genomes European ancestry samples (blue) and African ancestry samples (yellow). The table (bottom right) shows that genetics-based ancestry assignments were broadly consistent with reported categories in the “race” variable from HBCC.
