Fig. 4: Phenotypic variance explained by corresponding polygenic scores in the Human Brain Collection Core (HBCC).
From: Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort
Results for samples of European ancestry are on the left, and samples with African ancestry are on the right. Light gray denotes psychiatric phenotypes and dark gray denotes non-psychiatric phenotypes. Schizophrenia polygenic scores are the most powerful (left-most bars in both plots). Polygenic scores explain more phenotypic variance in European ancestry samples than samples with African ancestry. Note that three substance use polygenic scores (for alcohol, cannabis, and opioid phenotypes) were used to predict the same aggregate substance use phenotype in the HBCC samples. Two polygenic scores for anxiety were used (fs = factor score, cc = case control).
