Fig. 3: Chronic treatment with fluoxetine enhances synaptic plasticity in Shaffer collateral-CA1 synapses of the hippocampus. | Neuropsychopharmacology

Fig. 3: Chronic treatment with fluoxetine enhances synaptic plasticity in Shaffer collateral-CA1 synapses of the hippocampus.

From: Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants

Fig. 3

LTP induction after chronic treatment with fluoxetine. LTP was significantly enhanced 45 min after tetanic stimulation in wild-type mice treated with fluoxetine compared to control (two-way ANOVA, treatment, wild-type, F (1, 414) = 50.20, P < 0.0001) but not in PV-TrkB hCKO mice (treatment, F (1, 40) = 0.2726, P = 0.6019). Bars indicate mean ± SEM.

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