Fig. 4: Effect of LSD on inhibitory self-connections.

A t-statistic of the difference between LSD and placebo conditions in self-connections. B Top 10 self-connections ranked by t-statistic of the difference between LSD and placebo conditions. C Anatomical colourmap of t-statistic of the difference between LSD and placebo conditions in self-connections. D Estimates of feature importance of self-connections in EC classification model. E Top 10 self-connections by feature importance in the EC classification model. F Anatomical colourmap displaying feature importance of self-connections in the EC classification model. For (A), (C): Orange and blue areas indicate stronger and weaker connectivity under LSD, respectively. For (B), errorbars represent the across-participant standard deviation of the differences in connectivity between conditions. In (B) and (E), abbreviations indicate the ROIs forming each connection. For (E), errorbars represent the across-fold standard deviation of the feature importance estimates. PFr Prefrontal cortex, Fr Frontal cortex, Ins Insular cortex, Tem Temporal cortex, Par Parietal cortex, Occ Occipital cortex, SbC Subcortical regions, CeB Cerebellum, Ver Vermis, Bstem Brainstem.