Fig. 2: Distribution of subpopulations of DR neurons expressing MOR in drug-naïve mice.
From: Inhibition of dorsal raphe GABAergic neurons blocks hyperalgesia during heroin withdrawal
A Proportion of subpopulations of DR neurons expressing MOR mRNA. B, C DR topographic distribution of MOR-VGaT neurons. B MOR-VGaT neurons were more concentrated in DR lateral subregion (DRL) than DR ventromedial (DRV; *p = 0.0346) and DR interfascicular (DRI; *p = 0.0230) subregions; and more concentrated in the DR posterodorsal (PDR) than the DRV and DRI (*p = 0.0296, #p = 0.0210) subregions. C DR rostrocaudal distribution of MOR-VGaT neurons. D, E DR topographic distribution of MOR-VGluT3 neurons. D MOR-VGluT3neurons were more concentrated in DR dorsomedial (DRD) subregion than in DRL (**p = 0.0042), DRV (***p = 0.0005) and DRI (*p = 0.0186) subregions. E DR rostrocaudal distribution of MOR-VGluT3 neurons. F–G DR topographic distribution of MOR-VGluT3-TPH neurons. F MOR-VGluT3-TPH neurons were more concentrated in DRD subregion than in the DRL (**p = 0.0095), DRI (***p = 0.0010) and PDR (**p = 0.0070) subregions. G DR rostrocaudal distribution of MOR-VGluT3-TPH neurons. The data are expressed as mean ± SEM (n = 3 mice/group).
