Fig. 2: Hierarchical clustering of Euclidean distance matrices for control, stress only and stress-binge groups.

Modules were determined by cutting each dendrogram at 60% of the maximal height and are identified by magenta rectangles. A Number of modules for each group after trimming the hierarchically organized dendrogram at different percentages of the tree height. B Corresponding Euclidean distance of each brain region relative to the others in control mice. Five modules of coactivation were delineated. C Corresponding distance of each brain region relative to the others that were examined in stress only mice. Three modules of co-activation were delineated. D Corresponding distance of each brain region relative to the others that were examined in stress-binge mice. Six modules of co-activation were delineated. ACo Anterior cortical amygdaloid nucleus, AI Anterior insula, AIDV Agranular insular cortex, dorsal-ventral subdivision aPVT, paraventricular nucleus of the thalamus, anterior part, Arc Arcuate hypothalamic nucleus, BLA Basolateral amygdala, BMA Basomedial amygdala, CeA Central nucleus of the amygdala, CM Central medial nucleus of the thalamus, cVMH Ventromedial hypothalamic nucleus, central division; CxA Cortex-amygdala transition zone, DM Dorsomedial hypothalamic nucleus, dmVMH Ventromedial hypothalamic nucleus, dorsomedial division, DP Dorsal peduncular cortex, DR Dorsal raphe, DS Dorsal striatum, DTT Dorsal tenia tecta; dvAI; Ect Ectorhinal cortex, IL Infralimbic cortex, LA Lateral amygdala, lBNST Bed nucleus of stria terminalis, lateral division, lEnt Lateral entorhinal cortex, lHb Lateral habenula, lOFC Orbitofrontal cortex, lateral subdivision, LS Lateral septum, MS Medial septum, mAON Anterior olfactory nucleus, medial part, mBNST Bed nucleus of the stria terminalis, medial division; mCg, cingulate cortex, medial part; MeA Medial nucleus of the amygdala, mHb Medial habenula, mLH Lateral hypothalamus, medial division; mOFC Orbitofrontal cortex, medial subdivision; mPOA, medial preoptic area; NAcC, nucleus accumbens core; NAcSh, nucleus accumbens shell; PAG, periaqueductal gray; pAI, agranular insular cortex, posterior part; pAON, anterior olfactory nucleus, posterior part; PH, posterior hypothalamic area; Pir Piriform cortex, pLH Lateral hypothalamus, posterior division; pPVT, paraventricular thalamus, posterior part; PRh, perirhinal cortex; PrL, prelimbic cortex; PVN, paraventricular nucleus of the hypothalamus, medial parvicellular part; SNc Substantia nigra compacta; SNr, substantia nigra reticulata; VDB, nucleus of the vertical limb of the diagonal band; vlVMH, ventromedial hypothalamic nucleus, ventrolateral division; vOFC, orbitofrontal cortex, ventral subdivision; VP, ventral pallidum; VPM, ventral posteromedial thalamic nucleus; VPMpc, ventral posteromedial thalamic nucleus, parvicellular portion; vSub, ventral subiculum; VTA, ventral tegmental area; ZI, zona incerta.