Table 1 Demographics.

From: Effect of selective serotonin reuptake inhibitor treatment following diagnosis of depression on suicidal behaviour risk: a target trial emulation

 

Before IP weighting

After IP weighting

Initiator

Non-initiator

SMDa

Initiator

Non-initiator

SMDa

N

52917

109350

 

51676.8

109591.6

 

Female (%)

34213 (64.7)

68759 (62.9)

0.037

32745.4 (63.4)

69438.3 (63.4)

<0.001

Age category (years) (%)

  

0.229

  

0.039

  6–17

1760 (3.3)

9162 (8.4)

 

2966.9 (5.7)

7319.5 (6.7)

 

  18–24

8560 (16.2)

18107 (16.6)

 

8532.3 (16.5)

17869.7 (16.3)

 

  25–39

21438 (40.5)

44275 (40.5)

 

21029.3 (40.7)

44310.2 (40.4)

 

  40–49

12143 (22.9)

21840 (20.0)

 

10991.5 (21.3)

23067.4 (21.0)

 

  50–59

9016 (17.0)

15966 (14.6)

 

8156.9 (15.8)

17024.8 (15.5)

 

Family income category (%)

  

0.203

  

0.037

  <0

64 (0.1)

158 (0.1)

 

71.9 (0.1)

150.0 (0.1)

 

  0

460 (0.9)

1130 (1.0)

 

503.6 (1.0)

1070.1 (1.0)

 

  0 < x <= 20th percentile

10882 (20.6)

26360 (24.1)

 

11843.4 (22.9)

25132.0 (22.9)

 

  20th percentile < x <= 80th percentile

33291 (62.9)

64047 (58.6)

 

31259.1 (60.5)

65724.1 (60.0)

 

  >80th percentile

7203 (13.6)

12217 (11.2)

 

6308.8 (12.2)

13178.4 (12.0)

 

  NA

1017 (1.9)

5438 (5.0)

 

1690.0 (3.3)

4337.0 (4.0)

 

Education category (%)

  

0.192

  

0.031

  Primary

9133 (17.3)

20362 (18.6)

 

9429.1 (18.2)

19896.3 (18.2)

 

  Secondary

21370 (40.4)

39946 (36.5)

 

19725.9 (38.2)

41447.8 (37.8)

 

  Post-secondary

20385 (38.5)

40169 (36.7)

 

19458.1 (37.7)

40918.6 (37.3)

 

  NA

2029 (3.8)

8873 (8.1)

 

3063.7 (5.9)

7328.8 (6.7)

 

Family education category (%)

  

0.178

  

0.029

  Primary

4282 (8.1)

9588 (8.8)

 

4436.3 (8.6)

9382.0 (8.6)

 

  Secondary

20075 (37.9)

38437 (35.2)

 

18843.4 (36.5)

39588.1 (36.1)

 

  Post-secondary

26698 (50.5)

53186 (48.6)

 

25579.1 (49.5)

53893.1 (49.2)

 

  NA

1862 (3.5)

8139 (7.4)

 

2817.9 (5.5)

6728.4 (6.1)

 

Source of depression diagnosis (%)

  

0.288

  

0.033

  Primary care

41205 (77.9)

71257 (65.2)

 

36620.8 (70.9)

76039.7 (69.4)

 

  Outpatient care

10761 (20.3)

35847 (32.8)

 

14076.6 (27.2)

31419.2 (28.7)

 

  Inpatient care

951 (1.8)

2246 (2.1)

 

979.3 (1.9)

2132.8 (1.9)

 

Bipolar disorder diagnosis (%)

272 (0.5)

1390 (1.3)

0.081

464.7 (0.9)

1126.6 (1.0)

0.013

Anxiety disorder diagnosis (%)

22775 (43.0)

46992 (43.0)

0.001

22692.4 (43.9)

47536.2 (43.4)

0.011

Schizophrenia diagnosis (%)

414 (0.8)

1599 (1.5)

0.065

628.4 (1.2)

1375.8 (1.3)

0.004

Alcohol use disorder diagnosis (%)

3132 (5.9)

6563 (6.0)

0.004

3175.0 (6.1)

6635.1 (6.1)

0.004

Substance abuse disorder (excl. alcohol) diagnosis (%)

2376 (4.5)

5477 (5.0)

0.024

2599.3 (5.0)

5404.9 (4.9)

0.005

ADHD diagnosis (%)

1104 (2.1)

3580 (3.3)

0.074

1489.0 (2.9)

3183.3 (2.9)

0.001

Autism spectrum disorder diagnosis (%)

387 (0.7)

1309 (1.2)

0.048

560.9 (1.1)

1160.0 (1.1)

0.003

History of suicidal behaviour (%)

1256 (2.4)

2965 (2.7)

0.021

1353.8 (2.6)

2867.5 (2.6)

<0.001

Antipsychotic medication (%)

785 (1.5)

2189 (2.0)

0.040

1032.1 (2.0)

2069.4 (1.9)

0.008

Hypnotics and sedatives medication (%)

22758 (43.0)

23740 (21.7)

0.467

15464.1 (29.9)

31919.8 (29.1)

0.018

Benzodiazepine medication (%)

7298 (13.8)

5681 (5.2)

0.296

4393.7 (8.5)

9141.1 (8.3)

0.006

Antiepileptic medication (%)

635 (1.2)

2002 (1.8)

0.052

849.1 (1.6)

1811.1 (1.7)

0.001

ADHD medication (%)

398 (0.8)

1513 (1.4)

0.061

616.8 (1.2)

1306.2 (1.2)

<0.001

  1. aCovariate balance between initiators and non-initiators before and after inverse probability weighting at baseline.
  2. aSMD Standardised Mean Difference.