Table 2 Intention-to-treat and per-protocol analyses over 12 weeks, overall and by age.

From: Effect of selective serotonin reuptake inhibitor treatment following diagnosis of depression on suicidal behaviour risk: a target trial emulation

 

N events, initiators

N events, non-initiators

Absolute risk, initiators % (95% CI)

Absolute risk, non-initiators % (95% CI)

Risk difference % (95% CI)

Risk ratio (95% CI)

Intention-to-treata

 Overall

207

323

0.44 (0.37,0.50)

0.29 (0.26,0.32)

0.15 (0.07,0.22)

1.50 (1.25,1.80)

 6–17 years

47

67

2.26 (1.04,3.48)

0.78 (0.58,0.97)

1.48 (0.26,2.71)

2.90 (1.72,4.91)

 18–24 years

76

76

0.73 (0.54,0.92)

0.46 (0.34,0.57)

0.27 (0.05,0.49)

1.59 (1.11,2.28)

 25–39 years

54

94

0.26 (0.19,0.33)

0.21 (0.17,0.25)

0.05 (−0.04,0.13)

1.22 (0.86,1.73)

 40–49 years

18

45

0.14 (0.07,0.21)

0.21 (0.14,0.28)

−0.07 (−0.17,0.03)

0.67 (0.36,1.25)

 50–59 years

12

41

0.16 (0.04,0.28)

0.24 (0.16,0.31

−0.08 (−0.21,0.06)

0.67 (0.31,1.45)

Per-protocolb

 Overall

188

305

0.47 (0.34,0.60)

0.28 (0.23,0.34)

0.19 (0.05,0.33)

1.69 (1.20,2.36)

 6–17 years

45

61

2.41 (0.92,3.90)

0.72 (0.41,1.04)

1.69 (0.17,3.20)

3.34 (1.59,7.00)

 18–24 years

72

70

0.85 (0.50,1.21)

0.42 (0.25,0.60)

0.43 (0.03,0.83)

2.01 (1.12,3.60)

 25–39 years

48

93

0.27 (0.13,0.40)

0.21 (0.14,0.29)

0.05 (−0.11,0.21)

1.24 (0.65,2.35)

 40–49 years

15

42

0.14 (0.03,0.25)

0.20 (0.09,0.31)

−0.07 (−0.22,0.09)

0.68 (0.25,1.84)

 50–59 years

8

39

0.12 (−0.02,0.26)

0.23 (0.10,0.36)

−0.11 (−0.30,0.08)

0.53 (0.14,2.04)

  1. aIPW weighted for baseline treatment assignment using baseline confounders.
  2. bIPW weights for baseline treatment assignment (using baseline confounders only) are multiplied by time-varying weights for weighting by treatment adherence (using baseline confounders and time-varying indicators of treatment with other medications).
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