Table 1 Overview of key neuroplastic effects observed in patients receiving ECT.
Brain region | Neuroplastic effect | Correlation with outcome |
|---|---|---|
Hippocampus | Increased volume | No clear relationship with antidepressant response or cognitive effects |
Reduced anisotropy and diffusivity | Â | |
Increased functional connectivity to right temporal lobe, angular gyrus | Correlated with depressive symptom improvement | |
Anterior cingulate cortex | Increased thickness | Correlated with depressive symptom improvement (only in responders) |
Temporal cortex | Increased volume | Â |
White matter | Increased fractional anisotropy in specific pathways | Correlated with depressive symptom improvement |
Dorsolateral prefrontal cortex | Decreased global functional connectivity | Correlated with depressive symptom improvement |
Dorsomedial prefrontal cortex | Increased functional connectivity to posterior cingulate cortex | Correlated with depressive symptom improvement |
Default mode network | Increased functional connectivity within | Baseline connectivity related to depressive symptom improvement |
Increased functional connectivity to central executive network | Â |
