Fig. 1: CART has a sexually dimorphic effect on binge drinking. | Neuropsychopharmacology

Fig. 1: CART has a sexually dimorphic effect on binge drinking.

From: Cocaine and amphetamine regulated transcript (CART) mediates sex differences in binge drinking through central taste circuits

Fig. 1: CART has a sexually dimorphic effect on binge drinking.

A Schematic of experimental outline. B Male CART KO mice had increased cumulative (left) and total (right) while (C) female CART KO mice had decreased cumulative (left) and total (right) ethanol intake compared to WT littermates. D Δ intake of ethanol normalised to same-sex WT littermates revealed a sexually dimorphic role of CART in binge drinking. No differences in sucrose intake were seen in (E) male or (F) female CART KO mice compared to WT littermates, and (G) no sex difference in the role of CART in sucrose intake was observed. There were no differences in cumulative (left) and total (right) intake of ethanol supplemented with sucrose in (H) male or (I) female CART KO mice compared to WT littermates, and (J) no sex difference in the role of CART in sweetened ethanol intake was observed. Data presented as mean ± SEM. **p < 0.01, ***p < 0.001, ****p < 0.0001. n = 5–10/group. WT wildtype, KO knockout.

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