Fig. 2: CART KO reduces ethanol consumption and preference in female mice that can be elevated via sucrose supplementation. | Neuropsychopharmacology

Fig. 2: CART KO reduces ethanol consumption and preference in female mice that can be elevated via sucrose supplementation.

From: Cocaine and amphetamine regulated transcript (CART) mediates sex differences in binge drinking through central taste circuits

Fig. 2: CART KO reduces ethanol consumption and preference in female mice that can be elevated via sucrose supplementation.

A Schematic of experimental outline. Male CART KO and WT mice showed no difference in (B) ethanol intake, but CART KO mice had (C) reduced ethanol preference, (D) and increased total fluid intake compared to WT mice in a continuous access procedure. Female CART KO mice had reduced (E) ethanol intake and (F) preference, (G) no difference in total fluid intake compared to WT littermates a continuous access procedure. Female CART KO mice had reduced intake (H) and preference (I) for alcohol supplemented with sucrose, which was specific to 1% w/v sucrose supplementation, and (J) no differences in total fluid intake compared to WT mice. Data presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 n = 8–10/group. WT wildtype, KO knockout.

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