Table 2 Cognitive characteristics of the transdiagnostic cluster solution in discovery and replication sample.

From: Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness

 

Transdiagnostic

Impaired

Spared

HC

ANOVA

F

p fdr

Individual cluster comparisons

Discovery sample

 N

146

252

270

   

   soccog

−0.28 (1.14)

0.16 (0.87)

0.17 (0.74)

14.23

<0.001

imp < sp; imp < HC; sp = HC

   wm

−1.98 (2.08)

1.15 (2.04)

0.79 (1.97)

123.11

<0.001

imp < sp; sp > HC; imp < HC

   proc

−1.74 (1.85)

1.01 (1.76)

0.81 (1.52)

141.63

<0.001

imp < sp; imp < HC; sp = HC

   exfun

−0.66 (1.3)

0.38 (0.46)

0.32 (0.48)

106.82

<0.001

imp < sp; imp < HC; sp = HC

   att

−2.56 (3.55)

1.48 (2.46)

1.12 (2.42)

115.87

<0.001

imp < sp; imp < HC; sp = HC

   verbmem

−1.15 (1.43)

0.67 (1.16)

0.63 (1.09)

128.5

<0.001

imp < sp; imp < HC; sp = HC

   vismem

−1.39 (2.72)

0.81 (1.8)

0.73 (1.59)

68.81

<0.001

imp < sp; imp < HC; sp = HC

   sal

−0.23 (1.14)

0.13 (1.05)

−0.06 (0.95)

5.82

0.003

imp < sp; imp = HC; sp = HC

 WAIS

      vocab

9.26 (3.1)

11.52 (2.83)

11.82 (2.9)

39.68

<0.001

imp < sp; imp < HC; sp = HC

      matrix

9.09 (2.55)

11.05 (2.18)

11.14 (2.23)

44.15

<0.001

imp < sp; imp < HC; sp = HC

Replication sample

 N

161

128

120

   

   soccog

−0.61 (1.82)

0.73 (1.96)

0.17 (0.81)

24.17

<0.001

imp < sp; sp > HC; imp < HC

   wm

−1.72 (2.5)

1.64 (2.72)

0.79 (1.39)

83.71

<0.001

imp < sp; sp > HC; imp < HC

   proc

−2.78 (3.1)

0.47 (2.73)

0.81 (1.4)

85.62

<0.001

imp < sp; sp = HC; imp < HC

   exfun

−0.72 (1.18)

0.2 (0.9)

0.32 (0.44)

55.28

<0.001

imp < sp; sp = HC; imp < HC

   att

−4.85 (6.26)

2.12 (3.58)

1.12 (2.02)

100.87

<0.001

imp < sp; sp = HC; imp < HC

   verbmem

−0.39 (1.58)

1.04 (1.32)

0.63 (1)

43.16

<0.001

imp < sp; sp > HC; imp < HC

   vismem

−1.62 (3.37)

0.91 (2.17)

0.73 (1.55)

43.84

<0.001

imp < sp; sp = HC; imp < HC

   sal

−0.67 (1.6)

−0.76 (2.13)

−0.06 (0.85)

6.99

0.001

sp < imp; imp < HC; sp < HC

 WAIS

      vocab

9.72 (3.13)

11.32 (4.43)

12.65 (2.54)

25.24

<0.001

imp < sp; sp < HC; imp < HC

      matrix

9.7 (2.67)

11.49 (4.72)

11.94 (1.97)

18.62

<0.001

imp < sp; sp < HC; imp < HC

  1. soccog social cognition, wm working memory, proc processing speed, exfun executive functioning, att attention, verbmem verbal memory, vismem visual memory, sal salience, WAIS Wechsler Adult Intelligence Scale, vocab vocabulary subtest, matrix matrix subtest, fdr false-discovery rate correction, HC healthy controls, sp spared, imp impaired.
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