Fig. 1: Reduced hippocampal Dnmt3a1 levels impair memory formation.
From: Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1
A Schematic representation of viral constructs. B Representative images of the dorsal hippocampus of mice infected with Control-shRNA, Dnmt3a1-shRNA1 or Dnmt3a1-shRNA2. Scale bar: 100 µm. C Schematic representation of experimental design. Long-term (D) or short-term (E) spatial object recognition memory of mice expressing Control-shRNA (n = 7–12), Dnmt3a1-shRNA1 (n = 5–10) or Dnmt3a1-shRNA2 (n = 9–12). Dashed lines represent equal preference for either object (chance exploration). *p < 0.05, **p < 0.01 by two-tailed, unpaired t-test. Long-term (F) or short-term (G) contextual fear memory of mice expressing Control-shRNA (n = 9-11), Dnmt3a1-shRNA1 (n = 8-11) or Dnmt3a1-shRNA2 (n = 11-13). *p < 0.05 by two-tailed, unpaired t-test.
