Fig. 4: Hippocampal Neuropilin-1 is required for memory formation.
From: Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1
A Schematic representation of viral constructs. B Schematic representation of experimental design. C Long-term spatial object recognition memory of mice expressing Control-shRNA (n = 12), Nrp1-shRNA1 (n = 10) or Nrp1-shRNA2 (n = 10). Dashed lines represent equal preference for either object (chance exploration). *p < 0.05 by one-way ANOVA test followed by Dunnett’s multiple comparisons test. D Long-term contextual fear memory of mice infected with rAAVs expressing Control-shRNA (n = 11), Nrp1-shRNA1 (n = 12) or Nrp11-shRNA2 (n = 10). *p < 0.05 by one-way ANOVA test followed by Dunnett’s multiple comparisons test. ##p ≤ 0.01 by Kruskal-Wallis test followed by Dunn’s multiple comparisons test.
