Fig. 1: ASL preprocessing and analysis pipeline.
From: Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
A Diagram showing pipeline for region-of-interest (ROI) analysis. T1 images were preprocessed (1) and run through the MAGeT Brain toolbox (2), generating masks for grey matter, whole hippocampus, and hippocampal subfields. Using T1- > T2- > PD transformations calculated from registration (3 & 4), these masks were resampled (5) to CBF space (single resampling step) to allow for sampling of rCBF in native space (6). B Demonstration of optimum registration between CBF map, masks, and T1 images. C Schematic showing steps for voxel-wise analysis for CHR-P diazepam vs. placebo. A study-specific template was generated (1) from participant-averages (averaged structural scans from both drug conditions), and the CBF maps were resampled (2) to common space (single resampling step calculated from PD- > T2- > T1-> template transformations/deformations). hipp hippocampus, PD proton density, rCBF regional cerebral blood flow, ROI region-of-interest.
