Fig. 3: Binge-level MA consumption is dependent on non-functional TAAR1. | Neuropsychopharmacology

Fig. 3: Binge-level MA consumption is dependent on non-functional TAAR1.

From: Absence of TAAR1 function increases methamphetamine-induced excitability of dorsal raphe serotonin neurons and drives binge-level methamphetamine intake

Fig. 3: Binge-level MA consumption is dependent on non-functional TAAR1.The alternative text for this image may have been generated using AI.

A Total MA (mean ± SEM) consumption in mg/kg/18 h (day 2 and 4 average at each concentration) for each line at each MA concentration offered. **p < 0.01, ***p < 0.001 for the difference in MA consumed between the MAHDR-Taar1m1J/m1J and MAHDR-Taar1+/+ KI mice. Further analysis revealed a significant effect of MA concentration for MAHDR-Taar1m1J/m1J mice only. Within-subjects contrasts of means, +p < 0.05, ++p < 0.01 for the difference in MA consumed compared to the next lower MA concentration. B Total fluid (mean ± SEM) consumed by each line during the same 18 h period when each MA concentration was offered. **p < 0.01, ***p < 0.001 for the difference in total volume consumed between the MAHDR-Taar1m1J/m1J and MAHDR-Taar1+/+ KI lines. Further analysis revealed a significant effect of MA concentration for both the MAHDR-Taar1m1J/m1J line and MAHDR-Taar1+/+ KI line. Within-subjects contrasts of means, +p < 0.05, ++p < 0.01 for the difference in total volume at a given concentration compared to the previous MA concentration.) n = 40 mice (10 mice per line per sex).

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