Fig. 4: MA-induced potentiation of DR 5-HT neurons is dependent on non-functional TAAR1. | Neuropsychopharmacology

Fig. 4: MA-induced potentiation of DR 5-HT neurons is dependent on non-functional TAAR1.

From: Absence of TAAR1 function increases methamphetamine-induced excitability of dorsal raphe serotonin neurons and drives binge-level methamphetamine intake

Fig. 4: MA-induced potentiation of DR 5-HT neurons is dependent on non-functional TAAR1.The alternative text for this image may have been generated using AI.

Control refers to the firing frequency, activity, and RMP in the presence of antagonists for 5HT1A (WAY 100635, 100 nM) and 5HT1B (SB 216641, 200 nM) autoreceptors. A Mean firing frequency of MAHDR- Taar1m1J/m1J DR 5-HT neurons pre- and post-MA application [7 recordings (7 mice: Male=4, Female=3); Tukey’s HSD post hoc test, ***p < 0.001 for control compared to MA at a given current. Means ± SEM are presented collapsed on sex.] B Representative traces of MAHDR-Taar1m1J/m1J DR 5-HT recordings at 0 pA and +40 pA current injections in the absence (black) and presence of MA (teal). C RMPs of MAHDR-Taar1m1J/m1J DR 5-HT neurons were significantly depolarized by MA, *p < 0.05. Each set of symbols represents a recording in the absence and presence of MA. D Mean firing frequency of MAHDR-Taar1+/+ KI DR 5-HT neurons pre- and post-MA application [6 recordings (6 mice: Male=3, Female = 3). Means ± SEM are presented collapsed on sex] E Representative traces of MAHDR-Taar1+/+ KI DR 5-HT recordings at 0 pA and +40 pA current injections in the absence (black) and presence of MA (teal). F RMPs of MAHDR-Taar1+/+ KI DR 5-HT neurons were unchanged by MA. Each set of symbols represents a recording in the absence and presence of MA.

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