Fig. 3: Positive correlations between Marin Apathy Evaluation Scale (MAES) scores and regional [11C]CURB λk3 in the MDD group.

MDD participants who had higher MAES scores also had greater [11C]CURB λk3 binding in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), ventral striatum, and substantia nigra (r = 0.60 to 0.70, p = 0.01 to 0.03) but less so in the anterior cingulate cortex (ACC; r = 0.33, p = 0.27) and midbrain (r = 0.51, p = 0.08).