Fig. 1: Indicators of the inflammatory effect of CFA compared to baseline, 24 h after saline injection, and 24 h, 1 week, 2 weeks, and 3 weeks after CFA injection.
From: Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture
A Hindpaw swelling, measured as increased thickness in mm with a digital caliper (Time x Paw interaction: F(5,55) = 122.8, p < 0.0001; Sidak’s post hoc tests assessing between-groups differences in paw thickness at 24 h post-CFA: p < 0.0001). B Mechanical hypersensitivity, measured by reduced force required in grams for paw withdrawal (Time x Paw interaction: F(5,55) = 49.75, p < 0.0001; between-groups comparisons, p < 0.0001). C Representative images of each paw in a single mouse. Purple arrows indicate CFA-induced inflammation. *indicates a significant main effect of time (****p < 0.0001). #indicates a significant difference from baseline value (####p < 0.0001).
