Fig. 1: Effects of CBD on alcohol-related behaviors in alcohol dependent rats. | Neuropsychopharmacology

Fig. 1: Effects of CBD on alcohol-related behaviors in alcohol dependent rats.

From: Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum

Fig. 1: Effects of CBD on alcohol-related behaviors in alcohol dependent rats.The alternative text for this image may have been generated using AI.

A Time course of alcohol self-administration with CBD (30 mg/kg; green) or vehicle (yellow) during CIE exposure; two-way repeated measures ANOVA: significant time effect (F(5.248, 73.48) = 11.02, p < 0.001), no treatment or interaction effects. B Average responses in the alcohol-paired lever in the last 3 days pre- and post-vapor with CBD (30 mg/kg); two-way ANOVA: significant vapor effect (F(1,15) = 66.68, p < 0.0001). C Average responses in the water-paired lever in the last 3 days pre- and post-vapor with CBD (30 mg/kg). D Time course with CBD (60 mg/kg); two-way repeated measures ANOVA: significant time × treatment interaction (F(8,112) = 2.301, p = 0.0254). E Average responses in the alcohol-paired lever in the last 3 days pre- and post-vapor with CBD (60 mg/kg); two-way ANOVA: significant vapor × treatment interaction (F(1,14) = 7.198, p = 0.0178), Holm-Sidak post-hoc: vehicle escalation (p = 0.0003 vs. pre-vapor), blocked by CBD (p = 0.0059 vs. vehicle). F Average responses in the water-paired lever in the last 3 days pre- and post-vapor with CBD (60 mg/kg). G Progressive ratio breakpoint; unpaired t-test: t = 2.635, df = 14, p = 0.0196. H Blood alcohol levels; two-way ANOVA: no treatment (F(1,21) = 0.1407, p = 0.7114) or interaction effects (F(6,126) = 1.558, p = 0.1649), AUC: 450.1 ± 122.4 (CBD) and 501.3 ± 85.26 (vehicle). I Locomotor activity; unpaired t-test: t = 0.3923, df = 14, p = 0.7008. J Total somatic withdrawal signs; Mann-Whitney U = 1.000, p < 0.01; individual signs: Ventromedial Limb Retraction (VLR): U = 14.00, p = 0.133; tail stiffness: U = 15.00, p = 0.152; tremors: U = 16.00, p = 0.152 not significant. K Time in open arms (elevated plus maze); unpaired t-test: t = 2.949, df = 14, p = 0.0106. L Mechanical threshold (von Frey); unpaired t-test: t = 2.632, df = 14, p = 0.0197. Individual data points for male (blue circles) and female (pink circles) rats are shown. Data as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.

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