Fig. 4: Functional clustering and analysis of significantly hypermethylated transcripts in dorsolateral prefrontal cortex of MDD subjects.
From: M6A RNA epitranscriptome dynamics linked to major depressive disorder and suicide risk
A Gene ontology (GO) enrichment network plot showing the significantly impacted ontological functions associated with all significantly hypermethylated gene transcripts in MDD brain. The network was based on the betweenness connection to join the most related gene function nodes. The increasing and decreasing strength of connection between the two associated nodes is shown by a thick or thin line of edges. B The ridgeline plots display enrichment in various neuronal functions based on their connection to the coding gene with a significantly hypermethylated state in MDD brain. C PPi (protein-protein interaction) network based on the direct (physical) and indirect (functional) associations of significantly hypermethylated coding transcripts (in MDD) as obtained from STRING database. The network showing only those methylation-impacted genes that fulfilled the network joining criteria set at the STRING database.
