Fig. 2: DMT-induced energy changes in the connectome harmonic spectrum.

A A decrease of energy for low-frequency harmonics k ∈ [1,…,10²] (*p-value < 0.01, Bonferroni corrected paired t-test) and an increase of energy for high-frequency harmonics k ∈ [10³,…,10⁴] (*p-value < 0.01, Bonferroni corrected paired t-test) were observed. No significant changes were observed in the placebo conditions. B Furthermore, energy differences between the DMT and placebo conditions were observed with decreases in low-frequency harmonics k ∈ [1,…,10²] (*p-value < 0.01, Bonferroni corrected paired t-test) and increases in high- frequency harmonics k ∈ [10³,…,10⁴] (*p-value < 0.01, Bonferroni corrected paired t-test). No significant differences were observed at the inflexion point [10²,…,10³] (see Supplementary Table S1 for a full report of the p-values).