Fig. 3: A candidate screening, early detection and prevention pathway of care.
From: Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors
This diagram maps the sequential steps of a clinical screening and intervention algorithm that includes: (1) two sequential steps of screening, conducted using a symptom questionnaire followed by a clinical interview and/or an objective biomarker test; (2) repeat screening at regular intervals (e.g., annually) for those who screen negative; and (3) evaluation and intervention for those who test positive on both screening procedures. At the current time, the second screening test would likely consist of a clinical evaluation rather than an objective biomarker test, given that currently no such biomarkers have been sufficiently validated for this purpose (example hypothetical future biomarker included here: neuromelanin-sensitive MRI, a candidate marker of psychotic symptoms). The example intervention included here is the virtual reality-adapted version of Resilience Training, a four-session group intervention that aims to prevent worsening of transdiagnostic psychopathology in young adults [287,288,289].
