Fig. 1: Transcriptomic evidence for hyper-maturity in the mouse hippocampus.
a Patterns of differentially expressed genes (DEGs) in the hippocampus of particular strains/conditions of animals (mutants/conditions compared to wild-type/control animals) were compared with those in the DG of typically developing wild-type mice (8, 11, 14, 17, 21, 25, and 29 days old (d) young mice) compared to adults (34–36 weeks old (w)); GSE42778 and GSE113727) using Running Fisher test. b An example of transcriptomic immaturity. Gene expression in the DG of adult human immunodeficiency virus type I enhancer binding protein 2 (Hivep2) KO mice (DEGs between KO and wild-type mice) was compared with that of 14-day-old mice (DEGs between 14-day-old infant and 34–36-week-old adult mice). c–s Transcriptomic hyper-maturation observed in 17 hippocampal datasets from 16 mouse strains/conditions. Gene expression pattern in the hippocampus of PDE4A inhibitor-treated mice (c), the DG of GRov throughout the lifetime (d) and in early life (e) the hippocampus of Glud1 transgenic (Tg) mice (f, g), the hippocampus of Df(16)A+/− mice (h), the hippocampus of mice exposed to hypoxic conditions (i) and then normoxia (k), the DG of Sert homozygous (j) and heterozygous (q) KO mice, the hippocampus of GUSB mutant mice (l) the hippocampus of SAMP8 mice (m), the dorsal (n) and ventral (s) DG of corticosterone (CORT)-treated mice, the hippocampus of ME7 prion-infected mice (o), the hippocampus of Dclk1 Tg mice (p), and the hippocampus of Dicer KO mice (r) were compared with that in the DG of young mice of indicated age. The P values shown below each Venn diagram indicate the overlap P values for the comparison between the two datasets. The bar graphs below show the breakdown of the common genes between the two datasets, and the numbers above each bar represent the overlap P values for each comparison. These identified model mice are listed in ascending order of their overlap P values with the developmental data.
