Fig. 5: Cell-type contribution analysis of the gene expression signature related to accelerated aging. | Neuropsychopharmacology

Fig. 5: Cell-type contribution analysis of the gene expression signature related to accelerated aging.

From: Hyper-maturity and accelerated aging in the hippocampus of mouse models of neuropsychiatric disorders with anxiety-like behavior

Fig. 5

a Expression patterns of shared genes between each mouse model and aged mice (shaded) were compared with aging-related gene signatures from 11 cell types in the DG (16–21-month-old aged mice compared to 3-month-old young adult mice). b Plot showing the degree of similarity of gene expression patterns. The y-axis represents –log(overlap P-value), where higher values indicate greater similarity. Bubble size indicates the percentage of common genes relative to the accelerated aging signature genes (shaded in a).

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