Fig. 1: RRS elicits a depressive-like phenotype and increases the magnitude and duration of mechanical and heat hypersensitivity post-surgery. | Neuropsychopharmacology

Fig. 1: RRS elicits a depressive-like phenotype and increases the magnitude and duration of mechanical and heat hypersensitivity post-surgery.

From: Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats

Fig. 1

a Experimental design. The effect of RRS on (b) immobility time in the FST (**p <0.01) c faecal corticosterone levels (**p <0.01), d mechanical (von Frey) and e thermal heat sensitivity (Hargreaves test) during RRS and post-paw incision or sham surgery. ###p <0.001 no RRS + sham vs. no RRS + paw incision, *p <0.05, ***p <0.001 RRS + sham vs. RRS + paw incision, +p <0.05, ++p <0.01 +++p <0.001 no RRS + paw incision vs RRS + paw incision. n = 6/group.

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