Fig. 4: Blockade of spinal NLRP3 or IL-1β signalling attenuates RRS-induced exacerbation of pain-related aversion and mechanical hypersensitivity post-surgery. | Neuropsychopharmacology

Fig. 4: Blockade of spinal NLRP3 or IL-1β signalling attenuates RRS-induced exacerbation of pain-related aversion and mechanical hypersensitivity post-surgery.

From: Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats

Fig. 4

a Experimental design. The effect of intrathecal administration of MCC950 and IL-1Ra on (b, c) pain-related aversion (PEAP; day 2 (**P <0.01 ***P <0.001) and d, e paw withdrawal thresholds (von frey; Day 5) following paw incision surgery. ++p <0.01, +++p <0.001 No RRS + veh vs RRS + veh, ##p <0.01, ###p <0.001 no RRS + IL-1Ra/MCC950 vs RRS + IL-1Ra/MCC950, *p <0.05, **p <0.01 RRS + veh vs RRS + IL-1Ra. n = 6–8 per group.

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