Fig. 5: Chronic propranolol, but not RU486, attenuates RRS-induced exacerbation of post-surgical hypersensitivity, pain-related aversion and anxiety behaviour. | Neuropsychopharmacology

Fig. 5: Chronic propranolol, but not RU486, attenuates RRS-induced exacerbation of post-surgical hypersensitivity, pain-related aversion and anxiety behaviour.

From: Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats

Fig. 5: Chronic propranolol, but not RU486, attenuates RRS-induced exacerbation of post-surgical hypersensitivity, pain-related aversion and anxiety behaviour.

a Experimental design. The effect of chronic administration of glucocorticoid antagonist RU486 (21 days) on (b) immobility in the FST (*p <0.05), c pain-related aversion (PEAP Day 2 post surgery; **P <0.01) d time in the centre zone of the OFT (Day 4 post surgery, **P <0.01), e paw withdrawal threshold (von Frey) and f paw withdrawal latency (Hargreaves test). ++p <0.01, +++p <0.001 no RRS + paw incision + veh vs RRS + paw incision + veh, *p <0.05, **p <0.01, ***p <0.001 no RRS + paw incision + RU486 vs RRS + paw incision + RU486. The effect of chronic administration of propranolol (21 days) on (g) immobility in the FST (**p <0.01), h pain-related aversion (PEAP Day 2 post surgery; *P <0.05) i time in the centre zone of the OFT (Day 4 post surgery, *P <0.05 **P <0.01), j paw withdrawal threshold (von Frey) and k paw withdrawal latency (Hargreaves test). ++p <0.01, +++p <0.001 no RRS + paw incision + veh vs RRS + paw incision + veh, *p <0.05, **p <0.01, ***p <0.001 RRS + paw incision + veh vs RRS + paw incision + propranolol. n = 5–8 per group.

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