Fig. 3: Subtype-specific blocking of [18F]Flubatine in thalamus and cerebellum of human post-mortem brain tissue. | Neuropsychopharmacology

Fig. 3: Subtype-specific blocking of [18F]Flubatine in thalamus and cerebellum of human post-mortem brain tissue.

From: Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [18F]Flubatine PET images

Fig. 3: Subtype-specific blocking of [18F]Flubatine in thalamus and cerebellum of human post-mortem brain tissue.The alternative text for this image may have been generated using AI.

Mean binding (n = 3) is shown for total binding (0.1 nM [18F]Flubatine) and after blockade with A85380 (0.02 nM; α4β2*), α-conotoxin MII (1.5 nM; α6/α3β2*), and α-conotoxin PIA (5 nM; α6β2*). Connecting lines link paired measurements in thalamus A and the cerebellum C. Representative autoradiograms (left to right) display total binding and the three blocking conditions in the thalamus B and the cerebellum D. The scale denotes binding (nM).

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