Table 1 Clinico-demographic and imaging characteristics in healthy volunteer (HV) and schizophrenia (SCZ) groups.
HV (n = 26) | SCZ (n = 43) | Test-statistic | p value | |
|---|---|---|---|---|
Age (mean [SEM] years) | 35.92 (2.45) | 33.26 (1.82) | Mann–Whitney U = 483.00 | 0.35 |
Female, male (n) | 3, 23 | 7, 36 | Chi-square = 0.29 | 0.59 |
Taking antipsychotic medication (n) | – | 20 | – | – |
Duration of illness (mean [SEM] years) | – | 9.67 (1.65) | – | – |
WAIS-IQ (mean [SEM]) n: HV = 20; SCZ = 25 | 103.43 (3.85) | 93.44 (1.97) | T = 2.44 | 0.02 |
NART-IQ (mean [SEM]) n: HV = 21, SCZ = 33 | 114.80 (1.55) | 107.05 (1.99) | Mann–Whitney U = 217.50 | 0.02 |
NART-WAIS IQ difference (NART-IQ minus WAIS-IQ, mean [SEM]) n: HV = 19; SCZ = 23 | 10.34 (3.61) | 15.01 (2.51) | T = 1.09 | 0.28 |
Injected radioactivity (mean [SEM] MBq) | 260.35 (5.35) | 228.89 (8.25) | Mann–Whitney U = 366.00 | 0.02 |
[11C]UCB-J plasma free fraction (mean [SEM]) | 0.25 (0.005) | 0.26 (0.005) | Mann–Whitney U = 658.00 | 0.22 |
CS VT | 5.56 (0.11) | 6.16 (0.24) | Mann–Whitney U = 675.00 | 0.15 |
Whole brain grey matter [11C]UCB-J DVR (mean [SEM] ml/cm3) | 3.43 (0.09) | 3.07 (0.09) | T = 2.59 | 0.01 |
