Fig. 1: THC inhibits nociceptive firing. | Neuropsychopharmacology

Fig. 1: THC inhibits nociceptive firing.

From: The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaV1.7 and NaV1.8 nociceptive sodium channels

Fig. 1

A Representative whole-cell current-clamp recording from acutely dissociated rat nociceptive TG neurons in response to a current ramp (300 pA in 1 s; inset) before (left), during exposure to 0.1 µM TTX (middle), and during exposure to 10 µM THC (right). B Concentration-response relationship for inhibition of the AP firing by THC in nociceptor TG neurons. Box plots and individual values demonstrate changes in the number of APs following 4 min of exposure to THC at the indicated concentrations. The number of action potentials was normalized to the number of evoked action potentials before the application of THC. One-way ANOVA, followed by Bonferroni’s post hoc test when **, p ≤ 0.01; ***, p ≤ 0.001; ****, p ≤ 0.0001.

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