Fig. 5: hNaV1.7 and hNaV1.8 channels exhibit differential sensitivity to phytocannabinoids. | Neuropsychopharmacology

Fig. 5: hNaV1.7 and hNaV1.8 channels exhibit differential sensitivity to phytocannabinoids.

From: The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaV1.7 and NaV1.8 nociceptive sodium channels

Fig. 5

A Concentration-response curves for the inhibition of hNaV1.7 channels by cannabidiol (CBD; circles), Δ⁹-tetrahydrocannabinol (THC; squares), cannabichromene (CBC; triangles), and cannabigerol (CBG; diamonds). Peak current amplitude was normalized to the current before drug application (IX/IBefore) and plotted against the cannabinoid concentration. Solid lines represent fits of the data to the Hill equation. Each data point represents the mean ± SEM from at least n = 6 cells. hNaV1.7: [CBD: IC50 = 3.4 ± 0.3 µM; THC: IC50 = 8.4 ± 0.8 µM; CBC: IC50 = 5.1 ± 0.7 µM; CBG: IC50 = 3.3 ± 0.3 µM]. B Same as (A), but for hNaV1.8 channels. hNaV1.8: [CBD: IC50 = 0.8 ± 0.1 µM; THC: IC50 = 9.5 ± 0.6 µM; CBC: IC50 = 14.4 ± 1.4 µM; CBG: IC50 = 0.9 ± 0.1 µM].

Back to article page