Fig. 5: Functional connectivity.

Shown in Fig. 5a. highlighted in red are the connections between nodes i.e., degrees (a.) for the whole brain comprised of 139 brain areas. To the right are estimation plots for different brain regions. The estimation plots show the difference between vehicle (open circle) and PSI (closed circle) in the individual brain areas and there mean difference (closed squares). Included in each brain region is the p value and the average mean difference. Below in Fig. 5b. are radial maps showing the connections (lines) between the five brain areas that comprise the prefrontal cortex (large yellow dots) and surrounded brain areas color coded for their brain region. The enlarged circles highlight the brain regions most affected by early exposure to psilocybin.