Fig. 7: Protain associated epigenetic changes. | Neuropsychopharmacology

Fig. 7: Protain associated epigenetic changes.

From: Sex-dependent developmental changes in behavior, brain structure, functional connectivity, and sensory perception following exposure to psilocybin during adolescence

Fig. 7

A Western blots probed for REST, RCAN1, H3C3, PPP1R1B, AQP4 and beta-tubulin. B Quantification of the REST, RCAN1, H3C3, PPP1R1B, AQP4, and acetylated lysine normalized to beta-tubulin from each corresponding biological sample. Data were analyzed using a two-way ANOVA with Sidak’s correction and presented with error bars representing ± SD. *P < 0.05, **P < 0.002, ***P < 0.0002. Each lane represents a biological replicate with male/vehicle (n = 5), male/PSI (n = 4), female/vehicle (n = 3), and female/PSI (n = 6). RIPA soluble cerebral cortex, prelimbic cortex and prefrontal cortex. Sex x treatment interaction REST (F = 7.879, p = 0.014); RACN1 (F = 5.338, p = 0.036); H3C3 (F = 10.29, p = 0.0063); AQP4 (F = 5.181, p = 0.0391); Acetylated Lysine (F = 5.424, p = 0.0354); PPP1R1B (F = 2.716, p = 0.1216).

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