Fig. 3: Triazole 187 increases center time but does not induce sedation in male and female C57BL6/J mice. | Neuropsychopharmacology

Fig. 3: Triazole 187 increases center time but does not induce sedation in male and female C57BL6/J mice.

From: Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice

Fig. 3: Triazole 187 increases center time but does not induce sedation in male and female C57BL6/J mice.

A The distance traveled in male C57BL6/J is rapidly decreased by U50,488H (s.c.) while triazole 1.1 (s.c.) and triazole 187 (i.p.) do not produce this effect over time (time x dose, 2-way RM-ANOVA U50,488H: F(29.15, 309) = 2.501, p < 0.0001; triazole 1.1: F(15.87, 121.6) = 0.9740, p = 0.4888; triazole 187: F(66, 748) = 1.279, p = 0.0734). B The sum of the total distance traveled over 1 h and (C) the sum of horizontal activity (beam breaks) from the same mice are compared. D Female mice are compared for total distance and (E) horizontal beam breaks. F Comparison of time spent in the center compartment for male and (G) female mice. (males: n = Veh s.c.: 15; Veh i.p.: 16; U50: 8-10; Tri 1.1: 4; and Tri 187: 7-12; females: n = Veh s.c.,12; Veh i.p., 14; U50: 6-9; Tri 1.1: 6; Tri 187:10-12). Dose vs. vehicle comparisons were conducted using ordinary one-way ANOVA with Dunnett’s post-hoc test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Triazole 1.1 and U50,488H were administered s.c. and their vehicle is given via the same route. Triazole 187 and its vehicle were administered by the i.p. route. Potency (ED50) values with 95% CI and 2-way RM-ANOVA analyses for time are presented in Table 1.

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