Fig. 4: Triazole 187 increases time spent in open arms of the elevated plus maze in male mice and increases all arm entries and distance traveled in female mice. | Neuropsychopharmacology

Fig. 4: Triazole 187 increases time spent in open arms of the elevated plus maze in male mice and increases all arm entries and distance traveled in female mice.

From: Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice

Fig. 4: Triazole 187 increases time spent in open arms of the elevated plus maze in male mice and increases all arm entries and distance traveled in female mice.

Vehicle (i.p.), U50,488H (3 mg/kg, i.p.), triazole 1.1 (15 mg/kg, i.p.) or triazole 187 (5 mg/kg, i.p.) were administered to male mice (A–D) and vehicle or triazole 187 (5 mg/kg or 10 mg/kg, i.p.) were given to (E–H) female mice 30 min prior to the start of the 5-min test. Measures are presented as the percent of time spent in the open arms; the percent of time spent in the distal part of the open arm; the total number of arm entries; and the total distance traveled in the entire maze in 5 min. Data are presented as mean ± S.E.M. A Males: n = Veh i.p.: 18; U50: 18; Tri 1.1: 18; and Tri 187: 17; drug vs vehicle: (*p < 0.05, **p < 0.01 by one-way ordinary ANOVA, with Dunnett’s post-hoc test). B females: n = Veh i.p.: 18; and Tri 187: 10-16; triazole 187 compared to vehicle: (*p < 0.05, **p < 0.01 by one-way ordinary ANOVA, with Dunnett’s post-hoc test).

Back to article page