Table 1 ED₅₀ for mouse behavior assays in Figs. 2–4.

MALE MICE:	ED₅₀ mg/kg	95% CI	p vs U50	p vs 1.1
*Pruritis*
U50,488H	0.17	0.086–0.36
Triazole 1.1	0.58	0.30–1.11	0.0059
Triazole 187	0.16	0.027–0.69		0.0341
*Diuresis*
U50,488H	7.6	4.8–12
Triazole 1.1	87	50–188	<0.0001
Triazole 187	57	32–122	<0.0001
*Climbing^*
U50,488H	1.3	0.33–3.5
Triazole 1.1	41	21–91	<0.0001
Triazole 187	17	7.6–46	<0.0001
*Nesting*
U50,488H	0.85	0.45–1.4
Triazole 1.1	25	13–49	<0.0001
Triazole 187	9.2	4.7–19	<0.0001	0.0332
*Sedation (distance)*
U50,488H	3.3	2.1–5.0
Triazole 1.1	nc
Triazole 187	80	37–266	<0.0001
*Sedation (beam)*
U50,488H	3.1	2.0–4.6
Triazole 1.1	nc
Triazole 187	130	64–495	<0.0001
*Center Time^*
U50,488H	1.9	0.16–11
Triazole 1.1	nc
Triazole 187	5.6	2.6–11	<0.0001	0.0092
*Center Distance*
U50,488H	3.1	1.9–4.9
Triazole 1.1	nc
Triazole 187	56	27–148	<0.0001

FEMALE MICE:	ED₅₀ mg/kg	95% CI	p vs U50
*Sedation (distance)*
U50,488H	5.5	2.6–11
Triazole 187	29	16–60	0.0006
*Sedation (beam)*
U50,488H	5.7	3.6–8.9
Triazole 187	33	19–60	<0.0001
*Center Time^*
U50,488H	nc
Triazole 187	1.0	0.15–3.1
*Center Distance*
U50,488H	4.3	1.9–9.0
Triazole 187	122	43–∞	<0.0001

ED₅₀: Extra sum of squares F test (p = 0.05) comparing the normalized %MPE curves.
%MPE compared to U50,488H by unpaired t-test of the highest dose.
^afor Climbing, the max dose used is 10 mg/kg U50,488H;
^bfor Center time, the max dose used is 15 mg/kg of U50 for normalization and %MPE comparison.

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