Fig. 7 | Oncogene

Fig. 7

From: A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer

Fig. 7

Kmt2c and Kmt2d Mutations in the BBN tumors. (a, b) Top. Histogram displaying Kmt2d (a) or Kmt2c (b) frequently mutated regions calculated from aggregate TCGA genomes (missense, frameshift, and nonsense mutations were included). Bottom. List of variants found in Kmt2d (a) or Kmt2c (b) mapped to a diagram of the functional domains of the proteins. c IHC for Kmt2d was performed on tissue sections from normal bladders (left) or from BBN tumors expressing wild type (center) or mutant (L4197*, M4113K: right) Kmt2d. d Volcano plot showing upregulation of Kmt2d by RNA-seq in BBN tumors compared to control bladders (log2 fold change = 1.23; fdr-adjusted p-value = 0.0001)

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