Fig. 4
The long-term effects of MTL-CEBPA on SD rats exposed to CCl4 for 36 weeks. a MTL-CEBPA treatment for 14 weeks caused a significant benefit to survival. b All animals had developed ascites which escalated to grade 3 in the PBS control group whereas in the MTL-CEBPA group this was limited to grade 1–2. (Ascites scoring = 1: Mild ascites only detected by palpation; 2: moderate ascites causing moderate symmetrical distension of the abdomen and 3: large ascites cause visibly extended abdominal distension). Liver function tests on blood collected from SD rats exposed to long-term CCL4 induced toxicity. c Albumin and d total protein (globulin) remained raised when compared to the untreated control group. e ALT, f AST, g ammonia, h total bilirubin, i GGT and j ALP, k Body weight, and l prothrombin clotting time all collectively showed improvement in MTL-CEBPA treatment animals. All values represent mean ± SEM
