Table 2 Genes with statistically significant splicing identified by all three bioinformatics methods (FIRMA, MIDAS, ANOSVA) with five and more consecutive exon spliced
Gene symbol | Number of adjacent exons spliced | FIRMA scores | FIRMAp values | MIDAS scores | MIDASp values | ANOSVA p values |
|---|---|---|---|---|---|---|
RABGAP1L | 5 | 2.67 | 0.00009 | 2.08 | 0.029123 | 0.00557443 |
COL5A2 | 11 | −2.69 | 0.0001 | 3.78 | 0.018022 | 5.59315E−12 |
THBS2 | 8 | −2.13 | 0.00012 | −2.82 | 0.026826 | 1.82292E−10 |
CAPRIN1 | 4 | −2.71 | 0.00016 | 1.77 | 0.016125 | 0.00401313 |
CCT2 | 5 | −2.91 | 0.00017 | −5.31 | 0.034639 | 1.66782E−08 |
PTK2 | 4 | −2.47 | 0.00024 | 1.05 | 0.029415 | 0.000841486 |
CAND1 | 7 | 2.94 | 0.00036 | 1.72 | 0.036665 | 1.18221E−05 |
ALCAM | 6 | 1.95 | 0.00036 | 1.49 | 0.042686 | 3.01511E−06 |
IARS2 | 6 | −2.16 | 0.00043 | 4.17 | 0.02786 | 0.00132895 |
GNAS | 4 | 2.09 | 0.00043 | 1.26 | 0.048403 | 3.58804E−06 |
CLSPN | 12 | −1.71 | 0.00045 | −2.78 | 0.018561 | 7.88203E−10 |
COL12A1 | 5 | −2.16 | 0.00049 | 3.61 | 0.017637 | 1.24805E−11 |
MANF | 8 | −1.69 | 0.00051 | 4.77 | 0.028571 | 1.57539E−08 |
ESYT1 | 4 | 1.78 | 0.00052 | −3.86 | 0.024699 | 6.8431E−07 |
SLC17A5 | 4 | −1.78 | 0.00054 | 3.04 | 0.030499 | 0.000364402 |
APP | 6 | −1.94 | 0.00064 | 2.25 | 0.044619 | 0.000200504 |
EZH2 | 4 | 4.95 | 0.00067 | 3.06 | 0.046242 | 2.39594E−10 |
TPX2 | 10 | −1.54 | 0.0007 | 2.58 | 0.048631 | 5.44606E−10 |
CCNA2 | 4 | −1.77 | 0.00072 | 2.83 | 0.032232 | 1.44783E−10 |
TRIM33 | 8 | −2.05 | 0.00073 | 1.60 | 0.021483 | 0.00122048 |
GDE1 | 4 | −1.61 | 0.00076 | 2.90 | 0.045743 | 7.47662E−08 |
RDH10 | 4 | 1.95 | 0.00078 | 1.91 | 0.02083 | 0.000160419 |
ADAMTS9 | 10 | −1.96 | 0.00086 | −2.23 | 0.020655 | 0.000177544 |
LEMD3 | 7 | 2.09 | 0.0009 | 2.86 | 0.048904 | 0.000502659 |
BUB1 | 6 | −3.24 | 0.0009 | −2.30 | 0.020682 | 0.00287803 |
TNFRSF21 | 7 | 2.05 | 0.00098 | 3.26 | 0.030943 | 1.01738E−08 |
MTCH2 | 5 | −1.68 | 0.00099 | −3.38 | 0.013583 | 0.00801725 |