Fig. 7 | Oncogene

Fig. 7

From: The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition

Fig. 7

Diagram summarizing the role of HER4 in trastuzumab resistance regulation in HER2 positive gastric cancer. a MKN45TR or NCI-N87TR cells were treated with or without siYAP1 for 48 h and then incubated with or without 100 ng/ml NRG1 for 20 or 30 min, respectively. Western blot analysis was conducted to detect the expression of Cleavage-caspase3 and Cleavage-caspase9. b Hypothetic model illustrating that HER4-YAP1 axis induced EMT by activating PI3K signal pathway to promote trastuzumab resistance. Meanwhile, HER4-YAP1 also inhabit apoptosis associated protein Cleavage-caspase3 and Cleavage-caspase9, which has closely relationship with trastuzumab resistance

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