Fig. 3

APOBEC3B expression positively correlates with PD-L1 and other immune checkpoint genes expression in NSCLC. a Correlations between APOBEC3B and PD-L1 mRNA in normal lung tissue (n = 110) and NSCLC samples (n = 1017) are shown. b PD-L1 protein expression levels were compared between APOBEC3B UP (112 samples with matched PD-L1 protein expression data) and APOBEC3B DOWN (99 samples matched) groups based on TCGA datasets. c PD-L1 mRNA expression levels were compared between APOBEC3B UP and APOBEC3B DOWN groups based on two NSCLC datasets, TCGA (n = 254 for both UP and DOWN group) and GSE72094 (n = 111 for both UP and DOWN group) and Cancer Cell Line Encyclopedia (CCLE) dataset (n = 47 for both UP and DOWN group). d Heatmap representation of relative mRNA expression levels of selected immune inhibitory checkpoints. e Quantitative analysis of immune checkpoints gene mRNA expression based on APOBEC3B expression status (n = 254 for both UP and DOWN group). Unpaired Student's t-test was performed and FDR adjusted P-values are shown