Fig. 4

APOBEC3B upregulation is associated with increased CD8⁺ T-cell infiltration in NSCLC. a CD8A and CD8B mRNA expressions were compared between APOBEC3B UP and APOBEC3B DOWN groups based on TCGA dataset. b The correlation between APOBEC3B expression status and tumor microenvironment immune types classified based on PD-L1 and CD8 expression. Positive PD-L1 and CD8 were defined as above-median expression. c and d Abundance of CD8⁺ immune cell infiltration was quantified based on mRNA expression data with TIMER (c) or CIBERSORT (d) (Wilcoxon test, details see methods). n = 254 for both APOBEC3B-UP and APOBEC3B-DOWN group