Fig. 1 | Oncogene

Fig. 1

From: The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth

Fig. 1

US28 mediates HCMV-enhanced GBM growth. a Representative spheroids and spheroid size of uninfected U251 cells, or U251 cells infected with HCMV strain TB40/E wild type, HCMV in which US28 was deleted (HCMV-∆US28) or strain Merlin wild type. Spheroids were generated using the hanging droplet method followed by culture on 0.75% agarose (n = 6 spheroids per group). b Neurospheres of GBM48 primary GBM cells upon infection with HCMV strain Merlin (n = > 80 neurospheres per group). Representative plots are shown. All scale bars represent 250 μm. Sizes of individual spheroids or neurospheres are plotted as percentages of non-infected with mean ± SEM. *P < 0.05, ****P < 0.0001 (unpaired t test)

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