Fig. 3 | Oncogene

Fig. 3

From: The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth

Fig. 3

Constitutive activity of US28 enhances GBM growth. a Sections of paraffin-embedded brains from US28-expressing orthotopic GBM model in mice, stained with hematoxylin (blue) and rabbit-anti-US28 antibodies (brown). Scale bars represent 100 μm (large panels) or 30 μm (small panel). b–d Orthotopic GBM model generated with inducible U251-FM-iUS28 cells or parental U251-FM cells in striatum of mice treated with either sucrose alone or doxycycline/sucrose in their drinking water. b, c In vivo tumor growth as quantified by bioluminescence imaging (n = 6 mice per group). d US28-positive tumors were externally visible (arrow)

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