Fig. 2
From: HMGA1/E2F1 axis and NFkB pathways regulate LPS progression and trabectedin resistance
Interference with HMGA1 inhibits cell proliferation, induces cell death, and impairs in vitro motility and invasion of SW872 liposarcoma cells. a Total cell lysates from SW872 cells were analyzed 24 an 48 h upon depletion for the expression of HMGA1, PARP, and Hsp70. Cell viability was evaluated by Trypan blue exclusion from three independent experiments (P < 0.001). b Apoptosis was evaluated by Annexin-V/PI flow cytometric assay. Cell death was presented as the means ± SD of triplicate experiments (P < 0.01). c Chemotaxis and chemoinvasion assays were performed to examine the effect of HMGA1 depletion on SW872 cells. Number of migrated and invading cells was presented as the means ± SD of triplicate experiments of each group (P < 0.0001)
