Fig. 5
From: HMGA1/E2F1 axis and NFkB pathways regulate LPS progression and trabectedin resistance
Trabectedin downregulates in vivo mesenchymal markers in MLS after neo-adjuvant chemotherapy. H&E sections and IHC analysis of HMGA1, E2F1, and vimentin in the bioptic sample of MLS tissues before therapy (a and c panels) and on the surgical sample obtained after trabectedin therapy (b and d panels). H&E sections and IHC analysis for the expression of HMGA1, E2F1, and vimentin of specimens derived from distant metastases of patient c whose tumor has progressed: superior limb metastasis (e), and parotid metastasis (f). (Scale bar = 30 μm)
