Fig. 2
From: TROY interacts with RKIP to promote glioma development
Effect of TROY knockdown on glioma development. (a) Subcutaneous glioma model mice induced by U87 stable transfectants (2 × 106) were imaged by IVIS. The U87 cells stably expressing scramble vector were the control. GFP signal in nude mice bearing xenografted tumors were presented. (b) The growth curves of tumors (n = 9 for each group). The x-axis represents time after glioma cells injection. The y-axis represents volume of tumors (V = L × (W)2/2). (c) Subcutaneous tumors harvested from nude mice 5 weeks post xenograft (n = 9). (d) Scatter diagram of individual tumor volume 35 days after implantation. Each symbol represents a single tumor. (e) H&E staining of brain sections from orthotopic glioma model mice 20 days after implantation with U87 stable transfectants (5 × 105). (f) The brains harvested from orthotopic glioma model mice 20 days after implantation were imaged by IVIS. (g) Overall survival were analyzed through Kaplan–Meier and a two-sided log-rank test. **P < 0.01vs control
