Fig. 8
From: TROY interacts with RKIP to promote glioma development
A schematic model for downstream signaling pathway of TROY/RKIP interaction in glioma RKIP interacts with upstream regulatory molecules of NF-κB (IKKα, IKKβ, NIK and TAK1) and negatively modulate activation of NF-κB (left). After FBS exposure, the RKIP are retained by TROY receptor through interaction. These retention subsequently attenuate the inhibitory effects of RKIP on the upstream active regulators of NF-κB and result in the liberation from the upstream inactive complex, IκB, which resulting in NF-κB activation. This activation can in turn lead to the downstream transcriptional activation of cell-cycle genes, promoting proliferation and cell cycles following extracellular stimulation (right)
